A clinical trial to study the effect of two drugs, rocuronium and cisatracurium in adults subjected to general anaesthesia.

A Comparative Study Of Intubating Doses Of Rocuronium And Cisatracurium In Adults Undergoing Elective Surgeries Under General Anaesthesia-A Double Blind Randomized Controlled Trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014201

Enrollment

Registered

2018-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- All adults undergoing elective surgeries under general anaesthesia

Interventions

Intervention1: Endotracheal intubation with rocuronium: To assess and compare the feasibility of intubation using rocuronium and cisatracurium. Control Intervention1: Endotracheal intubation with cisa

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients posted for elective surgeries under general anaesthesia 2) ASA 1 and 2 3) Mallampatti grade 1 and 2 4) Surgery with duration more than 30 minute

Exclusion criteria

Exclusion criteria: 1) Restricted arm positions or likely changes in arm position during surgery 2) Patients who require rapid sequence intubation 3) Patients undergoing laparoscopic surgeries 4) Patients on aminoglycoside therapy or those who may need it intraoperatively

Design outcomes

Primary

Measure	Time frame
a)Hemodynamic variables(Heart rate; systolic, diastolic and mean arterial pressure) will be recorded at successive intervals like T0, T1, T2, T3, T4, T5, T6, T7, T8 and Tn. b) Intubating conditions assessed and graded based on ease of passage of tube with or without coughing/bucking and vocal cord position.Timepoint: T0-Before induction. T1-After induction. T2-After injection of neuromuscular blocker. T3-Just after intubation. T4, T5, T6, T7, T8-At a successive interval of 2min each after T3. Tn-At a successive interval of 10min each after T8.	—

Measure

Time frame

a)Hemodynamic variables(Heart rate; systolic, diastolic and mean arterial pressure) will be recorded at successive intervals like T0, T1, T2, T3, T4, T5, T6, T7, T8 and Tn. b) Intubating conditions assessed and graded based on ease of passage of tube with or without coughing/bucking and vocal cord position.Timepoint: T0-Before induction. T1-After induction. T2-After injection of neuromuscular blocker. T3-Just after intubation. T4, T5, T6, T7, T8-At a successive interval of 2min each after T3. Tn-At a successive interval of 10min each after T8.

—

Secondary

Measure	Time frame
a) onset time of neuromuscular blockade b) clinical duration of neuromuscular blockade c) recovery index d) any adverse reaction to the drugTimepoint: a) Time from injection of neuromuscular blocker to 95% supression of twitch height b) Time from injection of neuromuscular blocker to 25% recovery of twitch height c)Time from 25% to 75% recovery of twitch height	—

Countries

India

Contacts

Public ContactDr Paramanand Reddy

Father Muller Medical College

harshaomega@gmail.com9980124362

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026