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Changes in periostin levels in blood of patients of asthma after treatment with inhaled steroids.

Changes in serum periostin levels in patients of bronchial asthma treated with inhaled corticosteroids â?? a prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/05/014189
Enrollment
40
Registered
2018-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Bronchial Asthma

Interventions

Intervention1: nil: nil

Sponsors

Lady Hardinge Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All (old or new) diagnosed patients of bronchial asthma (age group 18-55 years of either sex who will be started on inhaled corticosteroids (ICS) for the next 4 weeks according to GINA (global initiative for asthma) guidelines (standard treatment of care) coming to a medicine unit of Smt. Sucheta Kriplani Hospital, New DelhI (Out patient department/ In patient department) will be included. For Healthy Volunteers: 1. Attendants of the patients who are not having any known illness and are not on any type medication will be included with their consent. Further, any healthy person who is willing to participate will also be included.

Exclusion criteria

Exclusion criteria: 1. Patients who have taken corticosteroids in any form in last 4 weeks 2. Patient with any other co-existent and active pulmonary infection 3. Imminent respiratory arrest as indicated by- a.Drowsy/confused patient b.Paradoxical thoraco-abdominal movements with respiration c.Absent wheeze d.Bradycardia (pulse 4. Evidence of active infection on chest X-ray 5. Pregnancy 6. Clinical evidence of any connective tissue disorders 7. Unwillingness to give consent.

Design outcomes

Primary

MeasureTime frame
Comparison of levels of periostin in healthy adults with asthmatic patients. Change in serum levels of periostin in asthmatic patients on treatment with inhaled corticosteroids. Timepoint: 4 weeks

Secondary

MeasureTime frame
Correlation between asthma severity score as measured by SOA questionnaire and periostin level. Change in quality of life scores in asthma as measured by QOLtech AQLQ questionnaire, after treatment with inhaled corticosteroids Timepoint: 4 weeks

Countries

India

Contacts

Public ContactDr Lalit Kumar Gupta

Lady Hardinge Medical College

lkg71@rediffmail.com9868234013

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026