Effect of intra-articular pain relief cocktail on post-operative functional outcome in Total Knee Replacement.

To compare the functional outcome following use of local infiltration analgesia with combined spinal epidural analgesia versus combined spinal epidural analgesia alone in patients undergoing Total Knee Arthroplasty: Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014183

Enrollment

Registered

2018-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Intra-articular Local Infiltration analgesia (drug cocktail): Cocktail composition- Adrenaline 30mcg, morphine 8mg, methylprednisolone 40mg, ceftriaxone 750mg, bupivacaine 0.5%, normal

Eligibility

Inclusion criteria

Inclusion criteria: All patients with osteoarthritis of knee undergoing unilateral Total knee arthroplasty

Exclusion criteria

Exclusion criteria: Patients undergoing revision knee arthroplasty, patients with peripheral vascular disease in the affected limb, patients with deranged coagulation profile, patients with major neurological deficit and uncontrolled angina, patients operated under general anesthesia, patients with history of allergy to cocktail drugs under study, patients who are provided with any alternative method of post op pain relief except combined spinal epidural analgesia.

Design outcomes

Primary

Measure	Time frame
Post op pain using VASTimepoint: 6 hours, 24 hours and 48 hours post operative period	—

Secondary

Measure	Time frame
Range of motion knee jointTimepoint: 1st, 5th and 14th post op day	—

Countries

India

Contacts

Public ContactVarun Vig

AFMC

drajaydeepsud1969@gmail.com9579673904

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026