A Study to reduce the total dose of Propofol, a drug used to induce anaesthesia.

A RANDOMIZED CONTROLLED TRIAL ON THE EFFECT OF USING PRIMING PRINCIPLE ON THE INDUCTION DOSE REQUIREMENTS OF PROPOFOL AND HAEMODYNAMIC CHANGES OF STUDY SUBJECTS - PROPOPRIME

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014173

Enrollment

Registered

2018-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Induction of anaesthesia as assessed by loss of verbal response

Interventions

Intervention1: priming dose of Propofol: priming dose of Propofol (30% of the total calculated dose of 2mg/kg) and then the remaining dose was given until attainment of the end point- loss of verbal r

Eligibility

Inclusion criteria

Inclusion criteria: ASA â?? I or ASA â?? II age group 18-55 years elective surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patient refusal Pregnant and lactating women Patients allergic to study medications Patients with uncorrected hypotension Patients with valvular heart disease.

Design outcomes

Primary

Measure	Time frame
Reduction in total dose of Propofol required for induction of anaesthesiaTimepoint: Reduction in total dose of Propofol required for induction of anaesthesia	—

Secondary

Measure	Time frame
Reduction in dose related haemodynamic variation due to PropofolTimepoint: just after induction just after intubation 5 minutes after induction	—

Countries

India

Contacts

Public ContactDr Sandhya VV

Sree Gokulam Medical College And Research Foundation

drmadhuvelayuden@gmail.com04723041000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026