Health Condition 1: C509- Malignant neoplasm of breast of unspecified site Health Condition 2: null- Tissue blocks from women with non-metastatic, TNBC breast cancer, who are eligible for neoadjuvant chemotherapy and have received NACT under the ongoing randomized trial at TMC
Conditions
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: Tissue blocks from women with non-metastatic, triple negative breast cancer, who are eligible for neoadjuvant chemotherapy and have received NACT under the ongoing randomized trial at TMC (CTRI/2012/07/002802), will be included in the study. TNBC with available paired paraffin samples (pre-NACT and post-surgery) will be included.
Exclusion criteria
Exclusion criteria: Metastatic Breast Cancer patient Non TNBC
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify biomarkers to predict chemoresistance in tumors of TNBC patients receiving NACT with anthracyclines and taxanes with or without platinum chemotherapyTimepoint: After completion of Neo Adjuvant Chemotherapy receiving NACT with anthracyclines and taxanes with or without platinum chemotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify specific targetable pathways in women who have not achieved pCR Estimate the residual cancer burden (RCB) in these tumors by evaluating the post-NACT surgical specimen using standard technique Timepoint: After completion of Neo Adjuvant Chemotherapy | — |
Countries
India
Contacts
Public ContactDr Nita Nair
Tata Memorial Hospital
Outcome results
None listed