to analyse the markers of pain in the gum fluid after putting small holes in the gums

Assesment of single versus subsequent Microosteopertforation stimulated expression of IL-1 Beta levels during orthodontic tooth movement- A pilot study

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014121

Enrollment

Registered

2018-05-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Two time microosteoperforation in one side of maxillary arch: microosteoperfration will be done with propel orthodontics device Control Intervention1: one time microosteoperforation in

Eligibility

Inclusion criteria

Inclusion criteria: Cases of class II div I or bimaxillary protusion requiring bilateral 1st premolar extraction Age 15 to 25 Erupted canines, premolars and 1st molars No significant medical history or medication that would adversely affect the development of teeth or tooth movement Positive informed consent

Exclusion criteria

Exclusion criteria: Non compliant patient with inability to maintain oral hygiene history of any drug intake Previous orthodontic treatment Not wiling for informed consent

Design outcomes

Primary

Measure	Time frame
Biochemical changes of IL-1beta during microsteoperforationTimepoint: o hour 1 hour 24 hour 1 week 21 days 28 days 72 days 120 days	—

Secondary

Measure	Time frame
analysis of differential expression of IL-1Beta on single versus subsequent microosteoperforation in terms of inflammationTimepoint: o hour 1 hour 24 hour 1 week 21 days 28 days 72 days 120 days	—

Countries

India

Contacts

Public ContactDr Ritu Duggal

centre for dental education and research AIIMS

rituduggal@rediffmail.com7838390003

Outcome results