To compare the effect of use of both intravenous and intra articular injection of tranexamic acid with only intra-articular injection of tranexamic acid in reducing blood loss in total knee replacement patients in western india

To compare the efficacy of combined use of intravenous and Intra-articular injection of Tranexamic acid with intra-articular administration alone in reducing blood loss in Primary Total Knee Arthroplasty: Randomized controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014106

Enrollment

Registered

2018-05-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- All patients who are undergoing primary TKA Health Condition 2: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Tranexamic acid-intravenous and intra-articular combined vs intra-articular injection alone: Intervention is to give both intravenous and intra-articular TXA to one group of patients wh

Eligibility

Inclusion criteria

Inclusion criteria: In combined Group-1gm of TXA using I.V injection 15 mins before skin incision and 1gm of TXA using intra-articular intra operatively after closure of joint capsule in primary TKA Single group-Receives only 1gm of TXA intra-articular intraoperatively after joint capsule closure in primary TKA.

Exclusion criteria

Exclusion criteria: Patient unwilling for study-no consent Patients allergic to TXA Patient with known history of thromboembolic disease Patients with cardiovascular disease like MI Patients with history of cerebral vascular disease- stroke pre op renal dysfunction pre op coagulopathy plt less than 1.5lakh and INR more than 1.4

Design outcomes

Primary

Measure	Time frame
Compare Fall in Haemoglobin level,haematocrit and Drain outputTimepoint: post operative day Hb level on day 3, day 5 and day 14 Drain output is measured after 24 hours post surgery	—

Secondary

Measure	Time frame
To evaluate the amount of blood loss with combined (intravenous and intra-articular) TXA in primary TKA To evaluate amount of blood loss with only intra-articular administration of TXA in primary TKATimepoint: Post operative day1,3,5 & 14	—

Countries

India

Contacts

Public ContactYeshi Dorji

Armed Forces Medical College

anilortho2@gmail.com7875443895

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026