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Improvement in Cognitive functioning in Patients with Schizophrenia after cognitive retraining.

Development of a Computerized Neurocognitive Remediation Package And Phase II Trial For Assessment Of Its Efficacy In Cognitive Function Among Patients With Schizophrenia

Status
Recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/05/014095
Enrollment
60
Registered
2018-05-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Schizophrenia

Interventions

Intervention1: Experimental Group: Patient in the experimental group would be given neurocognitive remediation training using a neurocognitive training module package. The modules would target various

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Male or female between 18-45 years of age Meeting the DSM-5 clinical criteria for schizophrenia (APA, 2013) Patients currently stabilized on same antipsychotics for a period of at least 6 weeks Patients or primary caregiver with capacity and willingness to give informed consent. Both in-patients and out-patients Having basic familiarity & comfort with using computers Both Right and Left Handed Education up to Primary level

Exclusion criteria

Exclusion criteria: Presence of past or current co-morbid Axis I disorders including substance abuse/dependence (other than caffeine or nicotine) Any history of seizure EXCEPT those therapeutically induced by ECT History suggestive of any neurological or progressive neurological condition. Having Colour blindness or Blindness Hearing impairment Non-consenting individuals Visual or motor disability which may hinder use of computers.

Design outcomes

Primary

MeasureTime frame
- Cognitive function (Time Frame: At baseline, post-intervention and at 3 months follow up.) - Clinical improvement of cognitive symptoms relative to pre-treatment baseline (Time Frame: At baseline, post-intervention and at 3 months follow up). - WHODAS II (Time Frame: At baseline, post-intervention and at 3 months follow up). Timepoint: The short term effectiveness would be measured immediately after the completion of the rehabilitation program at 9 weeks

Secondary

MeasureTime frame
Clinical improvement of negative symptoms (PANSS) relative to pre-treatment baseline. Global clinical improvement on Clinical global Impression Timepoint: The short term effectiveness would be measured immediately after the completion of the rehabilitation program in the 9th week, after completion of the retraining.

Countries

India

Contacts

Public ContactGarima Joshi

All Indian Institute of Medical Sciences

garima.joshi@hotmail.com9582074001

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026