Health Condition 1: null- Refractory status epilepticus (RSE) is defined as status epilepticus that fails to respond to first- and any two drugs in the second-line anticonvulsant therapy
Conditions
Interventions
Intervention1: Propofol: Group 2 will receive Target controlled based propofol infusion
Intervention2: Control of seizure: Successful therapy:
The status epilepticus is completely controlled by the t
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Adults patients with status epilepticus of any etiology who have not responded to the first line drugs like lorazepam and any of the two second line drugs like phenytoin, valproate, levetiracetam will be included in the study.
Exclusion criteria
Exclusion criteria: 1. No consent from the patientâ??s care-giver 2. Known allergy to the study drug 3. Patients having history coronary artery disease, documented clinical or echocardiac evidence of left ventricular dysfunction 4. Patients in shock
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Control of clinical seizuresTimepoint: Successful therapy: The status epilepticus is completely controlled by the therapy, without breakthrough or withdrawal seizures, or discontinuation due to side-effects, or death during the therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of ICU stay 2. Length of hospital stay 3. Duration of mechanical ventilation 4. Extended Glasgow outcome scale (GOS) /modified Rankin scale at the time of discharge 5. Systemic side effects a. Respiratory infection according to CDC guide lines b. AKI according to AKI guide lines c. Ionotropic support and duration of ionotropes. Timepoint: Extended Glasgow outcome scale (GOS) /modified Rankin scale at the time of discharge | — |
Countries
India
Contacts
Public ContactDr Gopalakrishna K N
National Institute of Mental Health and Neurosciences
Outcome results
None listed