Health Condition 1: null- Patients undergoing elective on-pump cardiac surgery with expected prolonged cardiopulmonary bypass duration more than 2 hours Health Condition 2: I080- Rheumatic disorders of both mitraland aortic valves
Conditions
Interventions
Intervention1: N-Acetylcysteine (Group N): In group N, 150 mg/kg N-Acetylcysteine IV in 200 ml 5% glucose over 15 minute, immediately after induction of anaesthesia prior to surgical incision, followe
Sponsors
Dr Ram Manohar Lohia institute of Medical Sciences Lucknow
Eligibility
Inclusion criteria
Inclusion criteria: Expected prolonged CPB duration ( >2 hours) Valve surgery, CABG and CABG with valve on-pump Written informed consent
Exclusion criteria
Exclusion criteria: Age 65 years Known allergy to N-Acetylcystine Emergency cardiac surgery Known blood borne infectious disease Existing deranged LFT End stage renal disease Planned off-pump cardiac surgery No written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute change in liver function test from baseline to peak levelTimepoint: Postoperative day 0,1,2 and 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute renal dysfunction Timepoint: Postoperative day 0,1,2 and 3;Incidence of post-operative Atrial FibrillationTimepoint: Postoperative day 0,1,2 and 3 | — |
Countries
India
Contacts
Public ContactDr Rajeev Kumar
Dr Ram Manohar Lohia Institute of medical Sciences
Outcome results
None listed