Health Condition 1: null- Melasma or dark pigmentation on face
Conditions
Interventions
Intervention1: Cases of melasma: Cases of melasma and controls will be selected according to the criteria described above. Following an informed consent, cases will be examined clinically to confirm t
Sponsors
Indian Association of Dermatologists Venereolologists and LeprologistsIADVLLoreal Research Grant
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for cases 1. Age more than 18 years. â?¨ 2. Patients with bilateral, symmetrical light brown to dark, muddy brown macules and patcheson face with irregular, serrated and geographical borders, and diagnosed clinically as melasma. 3. Have not received treatment in the past 3 month. â?¨ Inclusion criteria for controls 1. Age more than 18 years. â?¨ 2. Age and sex matched controls not having melasma
Exclusion criteria
Exclusion criteria: Exclusion criteria for cases 1. History of hypertension, diabetes mellitus, tuberculosis or any chronic renal or hepatic diseases. 2. Immunocompromised patients. â?¨ 3. Chronic cigarette smoking or alcohol intake. â?¨ 4. History of ingestion of oral contraceptives, folic acid, glutathione, vitamins E or C, selenium, zinc or iron, antidepressants in the last three months. 5. Patients who work in shift duties, have undertaken international travel in last 4 weeks or suffer from sleep disturbances or neuropsychiatric disorders Exclusion criteria for controls 1. History of hypertension, diabetes mellitus, tuberculosis or any chronic renal or hepatic diseases. 2. Immunocompromised patients. 3. Chronic cigarette smoking or alcohol intake. 4. History of ingestion of oral contraceptives, folic acid, glutathione, vitamins E or C, â?¨selenium, zinc or iron, antidepressants in the last three months. 5. Those suffering from alopecia areata/seborrheic dermatitis/vitiligo/ acne/ rosacea/ skincancer/psoriasis/asthma. 6. Patients who work in shift duties, have undertaken international travel in last 4 weeks or suffer from sleep disturbances or neuropsychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxidative stress has been proposed as one of the most important triggering event in the etiopathogenesis of melasma. However there are very few studies that evaluate its role in melasma.There is no study evaluating role of melatonin in melasma although topical and oral melatonin is available as treatment in a single study.The primary outcome of this study will be to assess the role of melatonin and serum markers of oxidative stress in melasma.Timepoint: Nine months | — |
Secondary
| Measure | Time frame |
|---|---|
| The obtained values of tests in melasma group will be compared with those of control group, and correlated with Modified Melasma Area Severity Index.Timepoint: Nine months | — |
Countries
India
Contacts
Public ContactRashmi Sarkar
Department of Dermatology Maulana Azad Medical College and Lok Nayak Hospital New Delhi-110002
Outcome results
None listed