Comparison of spinal clonidine and buprenorphine for vaginal hysterectomy under spinal anaesthesia

Comparison of intrathecal clonidine and intrathecal buprenorphine in different doses and in combination for vaginal hysterectomy under subarachnoid block

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013907

Enrollment

Registered

2018-05-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Female patients undergoing elective vaginal hysterectomy

Interventions

Intervention1: Bupivacaine heavy 0.5% 3.6cc with Clonidine 30mcg total 3.8cc: Bupivacaine heavy 0.5% 3.6cc with Clonidine 30mcg total 3.8cc given preoperatively as spinal drug.Motor and sensory block

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1-2 Age 35-70 years Weight 40-70 kgs Height more than 150cms Patient undergoing vaginal hysterectomy under spinal anaesthesia

Exclusion criteria

Exclusion criteria: Patient refusal on more than one antihypertensive agent allergy to local anaesthetics contraindication to spinal anaesthesia like raised intracranial pressure,coagulation disorder,infection at spinal site,spinal deformity,hypovolemia

Design outcomes

Primary

Measure	Time frame
time for onset of blockade,The upper and lower levels of sensory block were assessed after giving spinal block till regression of blockTimepoint: Degree of sensory and motor blockade was assessed every minute for first 10 minutes, every 2 minutes for next 10 minutes, every 15 minutes for next 1 hour and every 30 minutes there on. The assessment was continued till complete regression of sensory and motor block	—

Measure

Time frame

time for onset of blockade,The upper and lower levels of sensory block were assessed after giving spinal block till regression of blockTimepoint: Degree of sensory and motor blockade was assessed every minute for first 10 minutes, every 2 minutes for next 10 minutes, every 15 minutes for next 1 hour and every 30 minutes there on. The assessment was continued till complete regression of sensory and motor block

—

Secondary

Measure	Time frame
postoperative pain relief and rescue analgesics if needed,time needed for postoperative ambulation,time needed for 2 level regression of block,side effects if anyTimepoint: After closure of skin incision till patient was kept in recovery till 6 hours postoperatively	—

Countries

India

Contacts

Public ContactDrSupriya Dsouza

Seth GS medical college and KEM hospital

Supriyalynettedsouza@yahoo.com9821904925

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026