A clinical trial to study the effects of three desensitizing agents in relieving dentine hypersensitivity.

Comparative evaluation of arginine containing dentifrice in reducing dentinal hypersensitivity- A randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013903

Enrollment

150

Registered

2018-05-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients suffering from Dentine hypersensitivity, also those who have gingival recession, abrasion, erosion, abfraction in the cervical third of the tooth.

Interventions

Intervention1: 8% Arginine containing dentifrice,: the agent is massaged onto the tooth exhibiting dentin hypersensitivity only once with a gloved finger by the investigator for a minute after the in

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects between the age group of 18- 50 years (inclusive), 2. Subjects who complain of hypersensitivity, also those with cervical erosion/abrasion or gingival recession. 3. Subjects who signed the informed consent form. 4. Subjects willing to participate in the study

Exclusion criteria

Exclusion criteria: 1. History of allergies or idiosyncrasies to dentifrice ingredients. 2. Gross oral pathology, chronic diseases, advanced periodontal disease, treatment for periodontal disease (within the previous 12 months). 3. Hypersensitive teeth with mobility greater than one as given by Miller. 4. Subjects with teeth that have extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or those teeth being used as abutments for removable partial dentures are also excluded from the study. 5. Subjects who are current users of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily analgesics. 6. Pregnant or lactating women, individuals who are participating in any other clinical study or who had participated in a desensitizing study, or who used any desensitizing agents within the previous three months.

Design outcomes

Primary

Measure	Time frame
Reduction in dentin hypersensitivity after single direct topical application of these agentsTimepoint: 30 days	—

Secondary

Measure	Time frame
To evaluate the efficacy of dentifrice containing Arginine in reducing dentinal hypersensitivity on single applicationTimepoint: 30 days	—

Countries

India

Contacts

Public ContactSamuel Raj

Manipal College of Dental Science

sh.acharya@manipal.edu9448127031

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026