A STUDY OF CENTRAL AND MIXED VENOUS OXYGEN SATURATION WITH OUTCOMES IN OPEN HEART SURGERY PATIENTS BETWEEN TWO GROUPS CONVENTIONAL GENERAL ANAESTHESIA AND COMBINED WITH REGIONAL ANESTHESIA

A STUDY OF CENTRAL AND MIXED VENOUS OXYGEN SATURATION, AND EARLY OUTCOMES IN PATIENTS UNDERGOING OFF PUMP CORONARY ARTERY BYPASS GRAFTING UNDER GENERAL ANAESTHESIA COMBINED WITH PERIOPERATIVE THORACIC EPIDURAL OR INTRAVENOUS ANALGESIA

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013902

Enrollment

Registered

2018-05-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with Coronary artery diseases require open heart bypass surgery

Interventions

Intervention1: Thoracic Epidural Anesthesia by Bupivacaine with General Anaesthesia: 0.25% of 10ml Bupivacaine in thoracic epidural space combined with general anaesthesia in Off-pump CABG patients Co

Eligibility

Inclusion criteria

Inclusion criteria: To investigate the impact of high thoracic epidural analgesia in patients undergoing off-pump coronary artery bypass surgery on: Mixed venous oxygen saturation Central venous oxygen saturation Early post operative outcome Specific Objectives: To investigate the impact of high thoracic epidural analgesia on early clinical outcome in patients undergoing off-pump coronary artery bypass surgery on: 1. To compare the central venous and mixed venous oxygen saturation during intra-operative period and time for extubation and length of postoperative ICU stay. 2. To compare stress response, inotropic /vasodilatory support, pain outcome and analgesia requirements. 3. To evaluate other outcomes: new arrhythmia, post-operative blood loss, perioperative myocardial infarction, neurologic events, infective complication, if present. 4. To evaluate any other adverse effects during the study period.

Exclusion criteria

Exclusion criteria: Patients with abnormal coagulation profiles, patients requiring salvage CABG, With cariogenic shock, associated heart valve pathology, anti-platelet therapy continuing, local infection, renal, metabolic, neurological,psychiatric disorders were excluded from the study

Design outcomes

Primary

Measure	Time frame
Mixed and central venous oxygen saturation were higher and less ICU stay and preoperative complications in thoracic epidural group than general anaesthesia group of patients undergoing off pump CABG at the end of surgeryTimepoint: Mixed and central venous oxygen saturation were higher during grafting and at end of surgery and ICU stay were less and less number of perioperative complications in thoracic epidural group than general anaesthesia group of patients undergoing off pump CABG	—

Measure

Time frame

Mixed and central venous oxygen saturation were higher and less ICU stay and preoperative complications in thoracic epidural group than general anaesthesia group of patients undergoing off pump CABG at the end of surgeryTimepoint: Mixed and central venous oxygen saturation were higher during grafting and at end of surgery and ICU stay were less and less number of perioperative complications in thoracic epidural group than general anaesthesia group of patients undergoing off pump CABG

—

Secondary

Measure	Time frame
Serum cortisol, serum lactateTimepoint: 5- 8 hr intraoperatively	—

Countries

India

Contacts

Public ContactDR SOMNATH DEY

Institute of Post Graduate Medical Education & Research, Kolkata

chaitali03@rediffmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026