Comparison of effect of Letrozole or Leuprolide for preparing the endometrium(lining of uterus) before transferring frozen embryos

RANDOMISED CONTROL TRIAL COMPRARING PREGNANCY OUTCOME USING LETROZOLE VERSUS GNRH AGONIST DOWNREGULATED HRT FOR ENDOMETRIAL PREPARATION IN WOMEN UNDERGOING FROZEN EMBRYO TRANSFER CYCLES

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013894

Enrollment

140

Registered

2018-05-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Infertility

Interventions

Intervention1: Letrozole (intervention): Tab letrozole 2.5mg starting from day3-day7 Control Intervention1: HRT CYCLE: HRT Cycle- Women will be stated on GnRH-agonist, Luprolide (Injection Lupride 0.5

Eligibility

Inclusion criteria

Inclusion criteria: Women undergoing FET with at least 2 embryo vitrified , normal endometrial cavity and willing to participate in study

Exclusion criteria

Exclusion criteria: Women undergoing IVF with severe male factor demanding ICSI or surgical sperm extraction , poor responders ( < 3 oocyte retrieved at ovum pick up ), adenomyosis / fibroid , uterine adhesions/uterine cavityâ??s unsuitable for IVF FET at pre IVF WORKUP, donor oocyte cycle

Design outcomes

Primary

Measure	Time frame
1)Clinical pregnancy rate 2)ongoing pregnancy rateTimepoint: 1)Clinical pregnancy rate 4wk after embryo transfer I.e 6wk POG 2)ongoing pregnancy rate 10 wk of embryo transfer or 12 wk POG	—

Secondary

Measure	Time frame
1)Implantation rate. 2)endometrial thickness and patternTimepoint: 1)6wk. 2) 2wk	—

Countries

India

Contacts

Public ContactGayathri M S

ALL INDIA INSTITUTE OF MEDICAL SCIENCE

malhotraneena@yahoo.com9891557707

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026