Health Condition 1: null- Patients undergoing elective intrancranial neurosurgery
Conditions
Interventions
Intervention1: Leukoreduced and non-leukoreduced blood components transfusion: â?¢ Patients receive non-leukoreduced blood components,
â?¢ Patients receive buffycoat depleted blood products, and
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Sponsors
All India Institute of Medical sciences AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: a) Patients undergoing elective intracranial meningioma neurosurgery. b)Received transfusion of more than 1 units of PRBCs during surgery
Exclusion criteria
Exclusion criteria: a) Patients 70yrs of age. b) Having received blood transfusion in less than 6 months prior to the surgery. c) Patient undergoing emergency neurosurgery. d) Patient with any form of active infection; respiratory, UTI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expected that after transfusion of leukoreduced blood components there are less than 20 % changes in cytokines (INF-γ) level in their blood as compared to non-leukoreduced blood component transfusion.Timepoint: We expected that after transfusion of leukoreduced blood components there are less than 20 % changes in cytokines (INF-γ) level in their blood as compared to non-leukoreduced blood component transfusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.There are less incidence of postoperative infections and 2.Reduces the length of stay of patients in ICU and hospitals and 3.Reduces the mortality in patients undergoing neurosurgery.Timepoint: 7 days and 30 days | — |
Countries
India
Contacts
Public ContactGopal Kumar Patidar
All India of medical Sciences
Outcome results
None listed