Health Condition 1: null- 1. adults between 20-50 years age 2. those undergoing day-care gynecological laparoscopy 3. ASA class 1-2
Conditions
Interventions
Intervention1: Aprepitant: To prevent post-operative nausea and vomiting 80 mg aprepitant capsule is given per oral 1 hour before surgery
Intervention2: Aprepitant-Dexamethasone-Ondansetron-: To prev
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. female patients aged 20-50 years 2. ASA class 1 or 2 3. procedure- gynecological laparoscopy
Exclusion criteria
Exclusion criteria: 1. cardiovascular, respiratory, gastrointestinal diseases, diabetes 2. previous history of postoperative nausea and vomiting 3. pre-operative use of antiemetics or opioids 4. pregnancy 5. allergy to any of the three drugs under study 6. NPO inadequate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence and severity of postoperative nausea and vomiting after day-care gynecological laparoscopy following triple therapy with aprepitant,ondansetron and dexamethasone, when compared to oral aprepitant alone and ondansetron-dexamethasone combinationTimepoint: Nausea and vomiting will be noted immediately after extubation and post-operatively at 1st hour,2nd hour, 3rd hour and 4th hour | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration from surgery to DischargeTimepoint: Within 24 hrs | — |
Countries
India
Contacts
Public ContactDr Ingilala Lakshmi Thanuja
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed