A clinical trial to study the effect of 3 drugs esmolol, diltiazem and lignocaine in controlling heart rate and blood pressure response in an effort securing airway tube in patient undergoing abdominal surgery under general anaesthesia.

Comparison of intravenous esmolol, diltiazem and lignocaine in attenuation of hemodynamic response to direct laryngoscopy and intubation in patient undergoing abdominal surgery under general anesthesia: randomized, prospective, placebo control, double blind study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013862

Enrollment

120

Registered

2018-05-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: esmolol, diltiazem, lignocaine: group E- esmolol 0.2 mg/kg i.v bolus 3 minutes before laryngoscopy and intubation group D- diltiazem 0.2mg/kg i.v bolus 3 minutes before laryngoscopy and

Eligibility

Inclusion criteria

Inclusion criteria: Normotensive, ASA grade I and II, normal ECG

Exclusion criteria

Exclusion criteria: chronic hypertension, pregnancy, eclampsia, bronchial asthma, bradycardia, previous myocardial infarction, cerebrovascular insufficiency,patient receiving anti-hypertensive, antiarrythmic drugs,significant systemic disease, history of allergy to test drugs, patient not otherwise in inclusion criteria.

Design outcomes

Primary

Measure	Time frame
heart rate, systolic BP,diastolic BP, mean arterial pressure, rate pressure productTimepoint: before induction,immediately after intubation and at 1 minute, 2, 3, 5, 10, 15, 20, 25, 30, 45,60 minutes after intubation	—

Secondary

Measure	Time frame
heart rate, systolic BP,diastolic BP, mean arterial pressure, rate pressure productTimepoint: at 2 hours post operative period	—

Countries

India

Contacts

Public ContactSunita Doley

Institute of Medical Sciences, BHU

raviverma54@gmail.com9450950525

Outcome results