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Comparison of effect of Mannitol and 3% saline on cerebral hemodynamics of head injury patients

A prospective study to compare effect of mannitol and 3% hypertonic saline on cerebral hemodynamics in head injury patients.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/05/013830
Enrollment
20
Registered
2018-05-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Head Injury Patients

Interventions

Intervention1: Mannitol 20%: 2.5 ml/kg, Intravenous, administered once over ten minutes Control Intervention1: 3% Hypertonic Saline: 2.5 ml/kg, Intravenous, administered once over ten minutes

Sponsors

NONE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Postoperative moderate to severe head injury patients 2.Type of injury- Subdural hemorrhage, contusion, depressed fracture 3.Isolated head injury

Exclusion criteria

Exclusion criteria: 1.Polytrauma/Extracranial injury 2.Extradural Hemorrhage 3.Evidence of meningitis or intracranial infection 4.Multiorgan dysfunction 5.Inadequate transtemporal window for TCD 6.No consent from the patientâ??s care-giver 7.Patients in shock

Design outcomes

Primary

MeasureTime frame
Changes in the middle cerebral artery (MCA) Systolic cerebral blood flow velocity (CBFV) during the first 120 min (10, 30, 60 and 120 min) after administration of mannitol or 3% saline.Timepoint: End of 120 minutes after hypertonic agent administration—

Secondary

MeasureTime frame
1.Change in Cardiac output (CO) at 10,30,60,120 minutes time points 2.Correlation of cardiac output with CBF Timepoint: End of 120 minutes after hypertonic agent administration—

Countries

India

Contacts

Public ContactDeepti B Srinivas

National Institute of Mental Health and Neuro Sciences

gsuma123@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026