Health Condition 1: null- Newly diagnosed patients of major depressive disorder (DSM-5)
Conditions
Interventions
Intervention1: Bupropion: Class - Antidepressant, Dose - 150 - 300mg, Frequency - once daily, Route of administration- Oral, Total duration of therapy - 12 weeks
Control Intervention1: Paroxetine: Cla
Sponsors
UCMS and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Patients of either sex with age between 18 -60 years. 2. Patient must meet DSM-5 (fifth edition of diagnostic and statistical manual of mental disorders) criteria MDD (single or recurrent episode). 3. Patient Health Questionnaire (PHQ-9) score of at least 15 at screening. 4. Patients/guardian willing to give written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patients of acute suicidal risk. 2. Lifetime DSM-5 diagnosis of dementia, schizophrenia, schizoaffective or bipolar diseases, post-traumatic disorder, obsessive compulsive disorder, anxiety, eating disorder. 3. Substance dependency. 4. Depression due to organic brain disease. 5. Pregnant and lactating women. 6. Any significant medical illness (hypertension, diabetes, epilepsy, asthma chronic kidney disease, hypothyroidism). 7. Patients/guardian not willing to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Clinical evaluation: change in scores before and after 12 weeks of treatment with prescribed drugs 2. Biochemical evaluation: change in IFNγ and SEMA4D levels scores before and after twelve weeks of treatment with prescribed drugsTimepoint: 1. Clinical evaluation: change in scores before and after 12 weeks of treatment with prescribed drugs 2. Biochemical evaluation: change in IFNγ and SEMA4D levels scores before and after twelve weeks of treatment with prescribed drugs | — |
Secondary
| Measure | Time frame |
|---|---|
| noneTimepoint: 0 | — |
Countries
India
Contacts
Public ContactDr Seema Jain
UCMS and GTB Hospital
Outcome results
None listed