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Comparision between Levocetrizine versus combination of Levocetrizine and Desloratidine in the management of urticaria

Comparison of levocetirizine up-dosing versus combination of levocetrizine and desloratidine in chronic urticaria not responding to standard levocetrizine dose: An open-label parallel-arm randomized controlled trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/05/013808
Enrollment
240
Registered
2018-05-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patient having chronic spontaneous urticaria

Interventions

Intervention1: Levocetrizine: patients will be treated with double the dose of levocetrizine i.e. 10mg/day and will be re-evaluated after 2 weeks by UCT (visit 4). Those who are not well-controlled, l

Sponsors

Self
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a) Patients >18 years of age b) Patients fulfilling the definition of chronic spontaneous urticaria which is urticarial lesions occurring most days of the week (at least 3 times a week) lasting for 6 weeks or more with no identifiable cause on history or examination

Exclusion criteria

Exclusion criteria: 1. Patients not fulfilling the diagnosis of chronic spontaneous urticaria 2. Patients 3. Patients unwilling to participate in the study 4. Patients with physical urticaria, contact urticaria, drug-induced urticaria and urticarial vasculitis 5. Pregnant or breast-feeding female patients 6. Use of systemic steroids or other immunomodulators/immunosuppressants in the last 4 weeks; antihistamines in the last 7 days

Design outcomes

Primary

MeasureTime frame
â?¢ Proportion of patients achieving complete control of urticaria, as measured by urticaria control test (UCT)Timepoint: 6 weeks

Secondary

MeasureTime frame
â?¢ Proportion of patients achieving complete control of urticaria, as measured by urticaria control test (UCT)Timepoint: 7 weeks

Countries

India

Contacts

Public ContactDr V K Sharma

All India Institute of Medical Science

vksaiims@yahoo.co.in011-26593217

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026