A clinical study to evaluate the effect of drug simvastatin in treatment of jaw bone defects in between the teeth.

Efficacy of locally delivered simvastain combined with autologous platelet rich fibrin in treatment of intrabony defects: A Randomized control clinical trial.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013782

Enrollment

Registered

2018-05-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Intra-bony defects

Interventions

Intervention1: 1.2% Simvastatin gel: 1.2% Simvastatin is mixed with methylcellulose to form gel base and combined with autologous platelet rich fibrin. Control Intervention1: Autologous Platelet rich

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age range of 20-65yrs. 2.Presence of atleast on tooth on each side of mouth with probing depth and clinical attachment level>=5mm. 3.Radiographic evidence of interproximal intra osseous defect depth>=3mm

Exclusion criteria

Exclusion criteria: 1.Uncontrolled periodontitis. 2.Pregnancy or lactating women. 3.Patients with any systemic disorders

Design outcomes

Primary

Measure	Time frame
Bone fill occurring in the intrabony defects At 3 months and 6 months. Timepoint: Bone fill occurring in the intrabony defects At 3 months and 6 months.	—

Secondary

Measure	Time frame
1. Reduction in probing depth 2. Clinical attachment level gainTimepoint: 1. Reduction in probing depth - 0,3,6months 2. Clinical attachment level gain - 0,3,6 months	—

Countries

India

Contacts

Public ContactDr Gautami S Penmetsa

vishnu dental college

gautamipenmetsa@gmail.com9951011618

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026