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Comparing two drugs i.e. Nalbuphine and Dexmedetomidine in attenuating intubation response ( increase in blood pressure and heart rate while inserting endotracheal tube) in patients for surgeries under general anaesthesia.

A comparative study of nalbuphine and dexmedetomidine on haemodynamic response to tracheal intubation in patients for surgeries under general anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/05/013656
Enrollment
60
Registered
2018-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients undergoing elective surgery under general anaesthesia

Interventions

Intervention1: intravenous nalbuphine or dexmedetomidine drug before intubation: to give the said drugs before intubation to prevent the intubation response and compare the two drugs Control Intervent

Sponsors

Principal Dr RPGMC Kangra at Tanda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Male and female patients undergoing elective surgeries under general anaesthesia. 2.Amercian society of Anesthesiologist physical status I-II. 3.BMI between 18.5-29.9 Kg/m2

Exclusion criteria

Exclusion criteria: 1. Age 60yrs. 2. ASA grade 3 and 4. 3. History of allergy to any of study drugs. 4. Patients with peri-operative heart rate 5. Patients receiving other alpha 2 agonists like clonidine or other opioid. 6.Patients noted to have dysrhythmias on the electrocardiogram (ECG). 7.Unwilling patients. 8.Patients who are opioid tolerant or opioid dependent. 9.Pregnant women. 10.Anticipated difficult intubation. 11.Patient with cardiac, pulmonary, neurologic, kidney diseases.

Design outcomes

Primary

MeasureTime frame
To compare the changes in HR and BP after laryngoscopy and intubation.Timepoint: Haemodynamic response every 1 min till 5 min and there onwards at 10 min,20 min,30 min—

Secondary

MeasureTime frame
To study and compare PONV and sedation score. To observe for side effects of any of study drugs, if any.Timepoint: in interval of 2nd, 4th, 8th, 12th, 18th, 24th hour in post-operative period:—

Countries

India

Contacts

Public ContactDr Sudarshan Kumar

Dr. RPGMC Kangra at Tanda,HPU

sudarshan_58@rediff.com9418086604

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026