To study effect of drug dexmedetomidine in prevention of etomidate induced myoclonus and stress response at intubatuon

To compare effects of pretreatment with two doses of dexmedetomidine on etomidate induced myoclonus and attentuation of stress response at intubation.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013643

Enrollment

180

Registered

2018-05-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Age more than 18 and less than 65 years ASA I and II

Interventions

Intervention1: Dexmedetomedine: Inj. Dexmedetomidine infusion (0.5Âµg/Kg) in 10 ml Saline over 10 minutes followed by Inj. Etomidate (0.3 mg/Kg) over 30 seconds ,till lack of response to verbal comma

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II undergoing elective surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients with history to any study medications Anticipated difficult airway Known psychiatric disorder sepsis CAD Pacemaker or beta-blockers pregnancy

Design outcomes

Primary

Measure	Time frame
To compare the effects of pretreatment with two doses of dexmedetomidine on the incidence of etomidate induced myoclonus using numerical based gradingTimepoint: At the time of intubation	—

Secondary

Measure	Time frame
To compare the effects of pretreatment with two doses of dexmedetomidine on attenuation of stree response at laryngoscopy and intubation after induction with etomidateTimepoint: At the time of intubation and during surgery	—

Countries

India

Contacts

Public ContactDr P S Bhatia

V.M.M.C. AND SAFDARJUNG HOSPITAL

psbhatia2@rediffmail.com7042142230

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026