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COMBINATION OF THREE COMMONLY USED ANESTHETIC DRUGS -RANITIDINE , METOCLOPRAMIDE AND PROPOFOL GIVEN IN DIFFERENT COMBINATIONS TO PREVENT NAUSEA AND VOMITING DURING CAESARIAN SECTION IN PREGNANCY

THE EFFICACY OF A SINGLE PREANAESTHETIC SUBHYPNOTIC DOSE OF PROPOFOL IN ADDITION TO RANITIDINE AND METOCLOPRAMIDE IN THE PREVENTION OF NAUSEA AND VOMITING IN SPINAL ANAESTHESIA FOR CAESAREAN SECTION

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/05/013610
Enrollment
80
Registered
2018-05-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Post operative nausea and vomiting in LSCS

Interventions

Intervention1: Propofol in addition to Ranitidine and Metoclopramide: Patient is administered Injection Propofol 200microgram/kg IV in addition to tablet ranitidine 150mg and Metoclopramide 10 mg oral

Sponsors

Kasturba Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status 2 patients scheduled for Elective Caesarean Section under Spinal Anaesthesia

Exclusion criteria

Exclusion criteria: Patient refusal Age greater than 40 years ASA physical status III and IV Received antiemetics within 24 h before surgery History of Migraine /Motion sickness /PONV Received preoperative / intraoperative opioids Allergy to any of the drugs in the study All known contraindications to spinal anaesthesia Known history of substance abuse.

Design outcomes

Primary

MeasureTime frame
Incidence of Nausea and Vomiting during and after Spinal Anaesthesia and efficacy of propofol in prevention. ( VAS score )Timepoint: 1.Every ten minutes for the first hour intraoperatively 2. 0-4 hours postoperatively 3.4-12 hours postoperatively 4.12-24 hours postoperatively—

Secondary

MeasureTime frame
To compare hours of emesis free period between the two groupsTimepoint: 1.Every ten minutes for the first hour intraoperatively 2. 0-4 hours postoperatively 3.4-12 hours postoperatively 4.12-24 hours postoperatively—

Countries

India

Contacts

Public ContactDr Rashmi Ravindranathan

Kasturba Medical College, Mangaluru

pkaimar@yahoo.com9880094661

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026