Effect of glucose lowering drugs on some blood parameters in diabetic patients with and without retinal problems.

Correlation of tight glycemic control by antidiabetic medications with serum levels of monocyte chemoattractant protein(MCP-1) and cathepsin-D in type 2 diabetes with and without retinopathy.

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2018/05/013601

Enrollment

120

Registered

2018-05-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Type 2 diabetes with and without retinopathy

Interventions

Control Intervention1: Metformin, Glimepiride and insulin: Metformin- Biguanides, BD, oral for 12 months. Glimepiride- Sulfonylureas, OD, oral for 12 months. Insulin- Subcutaneous,as per physician dis

Eligibility

Inclusion criteria

Inclusion criteria: Type 2 diabetic patients with and without retinopathy taking treatment for atleast one year coming to Medicine and Ophthalmology Department.

Exclusion criteria

Exclusion criteria: 1. Patients with uncontrolled hypertension or recent acute cardiovascular event . 2. Pregnancy. 3. Unconscious patients/moribund patients. 4. Patients in whom fundus examination is not possible due to cataract or opacification of media.

Design outcomes

Primary

Measure	Time frame
To study the correlation of tight glycaemic control by antidiabetic medications with serum levels of MCP-1 and cathepsin-D in type 2 diabetes with and without retinopathy. Timepoint: 2 months	—

Secondary

Measure	Time frame
1. To correlate levels of serum MCP 1 and cathepsin D with diabetic retinopathy . 2. To assess the quality of life in diabetic patients with and without retinopathy by using questionnaire (WHOQOL-BREF). Timepoint: 2 months	—

Countries

India

Contacts

Public ContactDr Lalit Kumar Gupta

Lady Hardinge Medical College

lkg71@rediffmail.com9868234013

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 26, 2026