Success of locally applied drug in reducing gum disease

effectiveness of local delivery systems in reduction of Periodontitis- A split mouth randomized clinical trial

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013590

Enrollment

Registered

2018-05-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Systemically healthy patient with periodontal pocket depth of 5mm or more in posterior quadrant.

Interventions

Intervention1: Platelet rich plasma(PRP): Platelet rich plasma (PRP) is obtained from patient blood after centrifuging the blood with anti coagulant solution and mixing with 1ml solution of 10% calciu

Eligibility

Inclusion criteria

Inclusion criteria: 1)Pocket depth of 5mm or more in posterior quadrant 2)adequate attached gingiva 3)age group of 25-45yrs.

Exclusion criteria

Exclusion criteria: 1)Any systemic diseases, 2)Smoking, 3)Pregnant and lactating women, 4)If patient had taken antibiotics less than 6months

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of two delivery systems â?? 0.2% GENGIGEL gel and Platelet rich plasma (PRP) on clinical parameters pocket probing depth (PPD) and bleeding index (BI) of periodontitis after scaling and root planning(SRP).Timepoint: At baseline , 1 month and 3 months.	—

Secondary

Measure	Time frame
To assess the level of Nitric Oxide in gingival crevicular fluid (GCF) of both the local delivery systems.Timepoint: At baseline and 3 months	—

Countries

India

Contacts

Public ContactDr Meenakshi KJ

Amrita School Of Dentistry

rajvylo@gmail.com9961078433

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026