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A trial to compare efficiency of a drug used to reduce blood loss in surgical procedures when given through veins at different timings before, during and after surgery.

A comparitive study of efficacy of preoperative administration of single high dose intravenous tranexamic acid versus multiple boluses of intravenous tranexamic acid in primary total knee arthroplasty - TAKR

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/05/013588
Enrollment
300
Registered
2018-05-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Total blood loss in total knee replacement.

Interventions

Intervention1: Tranexamic acid will be administered in the study to evaluate its effect on decreasing total blood loss in total knee replacement when given through intravenous route as a single large

Sponsors

SUNSHINE HOSPITALS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Informed consent Those undergoing primary unilateral knee replacement.

Exclusion criteria

Exclusion criteria: Abnormal PT/APTT/INR or coagulopathic diseases Undergoing B/L TKR / revision surgeries of any cause Past h/o thromboembolic events Treated with Aspirin or any anti-platelets within 1 week prior to the surgery TKR done for secondary OA (rheumatoid arthritis, post traumatic arthritis) History of reported allergy to tranexamic acid Pre operative hemoglobin Chronic renal insufficiency

Design outcomes

Primary

MeasureTime frame
-Total blood loss -Change in hematocrit levels on post-operative day 2Timepoint: -Total blood loss -Change in hematocrit levels on post-operative day 2—

Secondary

MeasureTime frame
1.Transfusion rates 2.Deep vein thrombosis 3.Pulmonary embolisation rates -Operative timeTimepoint: 1.5th post operative day 2.90 days 3.90 days—

Countries

India

Contacts

Public ContactKRISHNA TEJA KANDRA

SUNSHINE HOSPITALS

kt18588@gmail.com9900280177

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026