A study to find out the efficiency of pain relief in using esmolol as an adjunct to morphine in breast surgeries.

Analgesic efficacy of perioperative esmolol as adjunct to morphine in mastectomy : A prospective observational study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/013571

Enrollment

140

Registered

2018-05-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Carcinoma Breast

Interventions

Intervention1: Esmolol group: All patients are premedicated with inj.morphine 0.1mg/kg. 10mins before the time of induction, Patients in esmolol group receives a bolus dose of 0.25mg/kg esmolol dilut

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing Modified Radical Mastectomy falling into ASA criteria 1 & 2

Exclusion criteria

Exclusion criteria: Male patients for mastectomy IHD Bronchial asthma Bradycardia Lung disease Cardiac failure Patients taking analgesic drugs regularly for other reasons

Design outcomes

Primary

Measure	Time frame
To evaluate the analgesic efficacy of esmolol given perioperatively in patients undergoing mastectomy under general anesthesia in terms of : 1) numerical rating scale for pain assessment 2) time to demand for first rescue analgesic 3) the number of bolus doses and total opioid consumption in 24 hrs postoperatively.Timepoint: 10 minutes, 2 hours, 6 hours, 12 hours, 24 hours post operatively	—

Secondary

Measure	Time frame
To evaluate the hemodynamic stability, any side effects like bradycardia and hypotension.Timepoint: Within 24 hours post surgery	—

Countries

India

Contacts

Public ContactDr Hema VR

Government Medical College, Kozhikode

drhemavr@gmail.com9847508866

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026