An Observational Study To Relate Two Biological markers with Left Heart Pressure And Blood Concentration of A Drug Dobutamine In Patients Undergoing By Pass Heart Surgery

A Study To Evaluate The Association Of Biomarkers With Pulmonary Capillary Wedge Pressure And Plasma Concentration Of The Inotrope Dobutamine In Patients Undergoing On-Pump CABG Surgery In A Super-Speciality Hospital At Coimbatore : A Prospective Observational Study

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

CTRI

Registry ID

CTRI/2018/05/013554

Enrollment

Registered

2018-05-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing Elective On-Pump CABG Surgery

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: CABG patients undergoing Elective On-Pump CABG surgery Co morbidities : Hypertension /Diabetes Mellitus /Thyroid dysfunction Mild to Moderate Left Ventricular Dysfunction

Exclusion criteria

Exclusion criteria: i. Patients undergoing Emergency CABG surgery ii. Patients undergoing Off-Pump CABG Surgery iii. Patients with preoperative unstable conditions such as: Congestive Cardiac failure Valvular Heart Disease Pulmonary Arterial Hypertension Abnormal Liver or Renal function iv. Chronic anti-inflammatory therapy. v. Therapy with recombinant BNP analogues. vi. Patients with immunodeficiency (AIDS,Leukemia,Lymphocytopenia)

Design outcomes

Primary

Measure	Time frame
To evaluate if the preoperative level of the cardiac biomarker NT-Pro BNP, correlates with intraoperatively measured Pulmonary Capillary Wedge Pressure (PCWP) in patients undergoing On-Pump CABG SurgeryTimepoint: Preoperative Plasma NT Pro BNP - 1 hour prior surgery Intraoperative PCWP - 0.5 h,1h,2h,3h intraoperatively	—

Secondary

Measure	Time frame
To evaluate the role of the inflammatory mediator TNF alpha on the postoperative plasma concentration of DobutamineTimepoint: Preoperative Plasma TNF -alpha - 1 hour prior surgery Plasma Concentration of Dobutamine and Plasma TNF - alpha levels - 4th hour from incision	—

Countries

India

Contacts

Public ContactDr R Subhashini

PSGIMSR , TamilNadu Dr MGR Medical University

nandabhuvana@gmail.com919894769934

Outcome results