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Study of effect of 5 oral agents on the pH of saliva after drinking a test flavoured milk

Comparison of five different salivary buffering agents on the changes in salivary pH in a cohort previously exposed to a test sweetened flavoured milk: A randomized controlled crossover trial. - SALPH-M

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013480
Enrollment
30
Registered
2018-04-25
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Group 2: tap water gargle: The subject collects the unstimulated saliva in a sterile glass dish for the measurement of baseline pH of the saliva. The subject is then given 100 ml of tes

Sponsors

Dr Meru S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. subjects in the age group of 18 to 30 years. 2. subjects with a DMFT index score of less than 2. 3. subjects with Loe and Silness Gingival index score of 0. 4. subjects willing to volunteer for the study. 5. subjects who are available for the whole study period of 4 months

Exclusion criteria

Exclusion criteria: 1. subjects with history of gastritis and bulimia. 2. subjects with chronic medical illness. 3. subjects with history of allergy. 4. subjects with history of drug intake for last 8 weeks. 5. subjects who smoke or chew tobacco

Design outcomes

Primary

MeasureTime frame
pH of saliva at baseline All subjects in all groups collects the unstimulated saliva in a sterile glass dish for the measurement of baseline pH of the saliva. The subject will give the saliva sample just before being exposed to the test mixed fruit juice by swishing 100ml of Amul Kool® Flavored Milk drink in mouth for 2 minutes and then drinking it The outcome accessor is blinded to origin of sample (from which group).Timepoint: 0 minutes

Secondary

MeasureTime frame
pH of Saliva 5 minutes after exposure to test flavored milk drink All subjects will be given 100 ml of test flavored milk drink, Amul Kool® Milk to drink. The subject will sip, swish and swallow the drink within 2 minutes. Five minutes after this, each subject will give unstimulated saliva in a sterile dish for measurement of saliva - 5minutes after exposure to test flavored milk drink. The outcome accessor is blinded to the origin of sample (from which group).Timepoint: 5 minutes;pH of Saliva 15 minutes after exposure to test flavored milk drink All subjects will be given 100 ml of test flavored milk drink, Amul Kool® Milk to drink. The subject will sip, swish and swallow the drink within 2 minutes. Fifteen minutes after this, each subject will give unstimulated saliva in a sterile dish for measurement of saliva - 15minutes after exposure to test flavored milk drink. The outcome accessor is blinded to the origin of sample (from which group).Timepoint: 15 minutes;pH of Saliva 30minutes after exposure to test flavored milk drink. All subjects from all six (5 test and 1 comparator) groups will perform assigned intervention at time 15minutes post exposure to test flavored milk drink, Amul Kool® Milk and shall give unstimulated saliva in a sterile dish for measurement of pH -30minutes after exposure to test flavored milk drink or in other words 15minutes after assigned intervention. The outcome accessor is blinded to origin of sample (from which group).Timepoint: 30 minutes;pH of Saliva 45minutes after exposure to test flavored milk drink. All subjects from all six (5 test and 1 comparator) groups will perform assigned intervention at time 15minutes post exposure to test flavored milk drink, Amul Kool® Milk and shall give unstimulated saliva in a sterile dish for measurement of pH -45minutes after exposure to test flavored milk drink or in other words 30minutes after assigned intervention. The outcome accessor is blinded to origin of sample (from which group).Tim

Countries

India

Contacts

Public ContactDr Prof Meru S

Uttaranchal Dental and Medical Research Institute

drmeru@gmail.com8126192404

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026