Study to compare the effect of a medicine (lignocaine) given by two ways,first one is by vapour (nebulisation)and second by injection into the blood to reduce the blood pressure and heart rate changes during the procedure of passing the tube into the wind pipe(trachea) tube to wind pipe

Comparison between intravenous and nebulised lignocaine for haemodynamic response to laryngoscopy and intubation

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/04/013462

Enrollment

Registered

2018-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Age group between 18 and 65years of either gender belonging to ASAPS 1 undergoing any surgery under general anaesthesia with endotracheal intubation.

Interventions

Intervention1: Group I: Group I receives 1.5 mg/kg of preservative free 2% lignocaine intravenously 90 seconds before laryngoscopy Intervention2: Group I: Group I receives 1.5 mg/kg of preservative fr

Eligibility

Inclusion criteria

Inclusion criteria: Elective surgical procedures under general anaesthesia requiring endotracheal intubation Age between 18 to 60 years age of either gender Modified Mallampati class I & II ASA PS I

Exclusion criteria

Exclusion criteria: 1. Anticipated difficult airway 2. Baseline heart rate 3. At risk for gastric aspiration 4. BMI > 30 kg/m2 5. Known allergy to lignocaine

Design outcomes

Primary

Measure	Time frame
hemodynamic response 1)Heart rate 2)Mean arterial pressureTimepoint: 1- Baseline value 2- Just before laryngoscopy 3- Immediately after laryngoscopy and intubation 4- Every minute after laryngoscopy and intubation for the first 5 minutes	—

Secondary

Measure	Time frame
Duration of laryngoscopyTimepoint: Should not exceed 15 seconds	—

Countries

India

Contacts

Public ContactShaji Mathew

KMC Manipal

kirz92cool@gmail.com9986373248

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026