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Steroids Thiamine and Vitamin C in Septic Shock

Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock - STACSS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013384
Enrollment
50
Registered
2018-04-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Septic Shock

Interventions

Intervention1: Intravenous hydrocortisone Intravenous ascorbic acid Intravenous Thiamine : Hydrocortisone 50 mg iv 6 hrly for 5 days Ascorbic acid 1.5 gm iv 6 hrly for 4 days Thiamine 200 mg iv 12 hr

Sponsors

Jaslok Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients admitted to the Critical Care Unit who demonstrate 2 or more of the following symptoms : Temperature 38 Pulse >90 bpm White Cell Count of 11000 Respiratory Rate >20 New Confusion Systolic BP 1h despite fluid resuscitation Culture positive or strong suspicion of infection with Procalcitonin level >2ng/ml

Exclusion criteria

Exclusion criteria: 1) Pregnant patients 2) Patients who die within 24 hrs of admission 3) Terminal illness

Design outcomes

Primary

MeasureTime frame
Reversal of shock: Off Vasopressors24h 28-Day Mortality Rate Timepoint: Reversal of shock: Off Vasopressors24h 28-Day Mortality Rate—

Secondary

MeasureTime frame
Procalcitonin clearance length of icu stay Timepoint: clearance at 72 hours—

Countries

India

Contacts

Public ContactShruti Tandan

Jaslok Hospital

shrutitandan@gmail.com9323868081

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026