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Does Helicobacter pylori infection of the stomach reduce/increase the chances of vomiting blood,in patients with liver disease

Association between variceal bleed and Helicobacter pylori infection in patients of cirrhosis with portal hypertension- a cohort study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/04/013357
Enrollment
220
Registered
2018-04-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Liver cirrhosis with portal hypertension

Interventions

None listed

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All cases of liver cirrhosis and portal hypertension with esophageal/ gastric/ esophago-gastric varices with or without previous episodes of bleeding

Exclusion criteria

Exclusion criteria: 1 Non-variceal causes of upper gastrointestinal bleeding 2 Patients on PPI or other drugs that reduce acid output in the last 6 weeks 3 Patients who have received H.pylori eradication in past 3 months 4 Patients not fit for endoscopy

Design outcomes

Primary

MeasureTime frame
1. Prevalence of H.pylori infection in patients with esophageal varices due to liver cirrhosis with portal hypertension 2. To correlate the prevalence of H.pyloriwith the incidence of bleeding/rebleeding from esophageal varices and encephalopathy in patients of cirrhosis with portal hypertension Timepoint: 18 months—

Secondary

MeasureTime frame
1. To correlate the site of bleeding in case of liver cirrhosis with portal hypertension with H.pylori infection 2. To determine the association of pepsinogen I & II and pepsinogen I/II ratio with variceal bleeding and H.pylori infection Timepoint: 18 months—

Countries

India

Contacts

Public ContactDr Varuna S

Jawaharlal Institute of Postgraduate Medical Education and Research

varun071992@yahoo.co.in9886998971

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026