Health Condition 1: null- Gynaecological Malignancy Health Condition 2: C51-C58- Malignant neoplasms of female genital organs
Conditions
Interventions
Intervention1: Dexmedetomidine, Ketamine
(Opioid free group): In this group, anaesthesia induction will be performed with a Dexmedetomidine bolus of 0.5 mcg/kg over 10 minutes (Infusion analgesic) alo
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: ASA I-II scheduled to undergo Elective open gynaecological oncology surgery under general anaesthesia
Exclusion criteria
Exclusion criteria: 1)Patients refusal 2)ASA III OR IV 3)Allergy to any of the study drugs 4)Contraindications to regional technique e.g., allergy to local anaesthetic drugs, infection around site of block ,any coagulation disorder, sepsis 5)History of analgesic dependence (long term use) and opiate tolerance 6)Pre-existing chronic pain with regular use of medications 7)Epilepsy and psychiatric disturbances
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to attain the PACU discharge criteriaTimepoint: post operative period 2 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid induced hyperalgesia (OIH)Timepoint: at PACU discharge and at 24 hours;Post-operative analgesic consumptionTimepoint: for 24 hours;Post-operative nausea and vomiting(PONV)Timepoint: till 24 hours;Quality of recovery as measured by QoR- 15 questionnaireTimepoint: at 12 and 24 hours;Time to extubationTimepoint: time from switching off inhalational agent to extubation;Time to first analgesic in PACUTimepoint: post operative period 2 hours;Time to shiftingTimepoint: time from switching off inhalational agent to shifting the patient out of theatre;VAS scoreTimepoint: on arrival in PACU | — |
Countries
India
Contacts
Public ContactKALAGARA RESHMA
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed