Health Condition 1: - Health Condition 2: null- acute exacerbations of Chronic obstructive pulmonary disease
Conditions
Interventions
Intervention1: magnesium sulfate infusion: magnesium sulfate infusion 2g in 100ml normal saline over 20-30mins was comapred to placebo as an adjuvant therapy to bronchodilators in acute exacerbations
Sponsors
Kempegowda institute of medical sciences
Eligibility
Inclusion criteria
Inclusion criteria: Subjects of either gender between 18- 65 years diagnosed as COPD grade 2/3 (GOLD criteria) presenting with symptoms of acute exacerbations and not requiring ventilation
Exclusion criteria
Exclusion criteria: subjects with severe COPD exacerbations requiring invasive ventilation and patients in respiratory failure and altered sensorium patients with TB, Bronchiectasis patients with a history of cerebrovascular disease,hepatic, cardiac, renal dysfunction, uncontrolled diabetes mellitus were excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary outcome- efficacy of Magnesium sulfate was estimated by measuring, PEFR(peak expiratory flow rates) at 0,15,30,45 minsTimepoint: primary outcome- efficacy of Magnesium sulfate was estimated by measuring, PEFR(peak expiratory flow rates) at 0,15,30,45 mins | — |
Secondary
| Measure | Time frame |
|---|---|
| Costs were estimated based on direct medical resources used for management of exacerbationsTimepoint: on discharge all hospital related costs were calculated | — |
Countries
India
Contacts
Public ContactNeethi Shelly Selvam
Kempegowda institute of medical sciences
Outcome results
None listed