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Comparison between two drugs (Gabapentin and Pregabalin) for post-operative pain management after spine surgery

Comparison between the pre-emptive use of Gabapentin versus Pregabalin for post-operative pain management in cases of lumbar laminectomy: A Randomized Comparative Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013305
Enrollment
60
Registered
2018-04-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients posted for elective lumbar laminectomy surgery under general anaesthesia.

Interventions

Intervention1: Drugs given as premedication: 2 separate drugs were given 1 hour prior to induction of anaesthesia and their efficacy evaluated in patients undergoing lumbar laminectomy surgery. Contro

Sponsors

B R Singh Hospital and Centre for Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients willing to comply with the post-operative follow up evaluations.

Exclusion criteria

Exclusion criteria: Known allergy to any of study medications Renal insufficiency, peptic ulcer disease or history of bleeding diathesis or liver disease.

Design outcomes

Primary

MeasureTime frame
To evaluate the postoperative analgesic efficacy of gabapentin 900 mg versus pregabalin 300mg in patients undergoing lumbar laminectomy surgery.Timepoint: Post-operatively at 1 hour, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours.

Secondary

MeasureTime frame
To assess and compare the haemodynamic parameters, efficacy in reducing the level of preoperative anxiety and level of postoperative sedation and side effects after administration of both drugs.Timepoint: Intraoperatively at induction of anaesthesia and 30 minutes till the end of surgery. Post-operatively at 1 hour, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours.

Countries

India

Contacts

Public ContactSrabani Basu

B R Singh Hospital and Centre for Medical Education and Research, Eastern Railway

drsrabonibasu@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026