Health Condition 1: null- GALL STONE DISEASE CHOLELITHIASIS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY
Conditions
Interventions
Intervention1: MAGNESIUM SULPHATE
: Patients in Magnesium sulphate group
received a IV bolus 40mg/kg in normal saline, followed by an IV infusion of 15mg/kg/hr. Bolus volume of the study drug was adj
Sponsors
Burdwan Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA Physical Status I and II 2. Age-18 to 50 years 3. Sex â?? Both Male and Female 4. Patients undergoing elective laparoscopic cholecystectomy
Exclusion criteria
Exclusion criteria: Following patients were excluded from this study:- 1. Patient refusal 2. ASA physical status III and IV, 3. Patients having difficult airway, 4. Bronchial asthma, Chronic Obstructive Pulmonary Disease or any other respiratory diseases, 5. Liver diseases, 6. Heart diseases, Conduction blocks 7. Hypertensive patients 8. Patients taking clonidine, methyl-dopa, beta blockers, benzodiazepines, MAO inhibitors 9. Morbid obesity, 10. Renal diseases, 11. Diabetes, 12. Neurological illnesses, Myopathies, and 13. Allergy to the study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart Rate (HR) and Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) & Mean Arterial Pressure ( MAP), oxygen saturation (SpO2) were recorded before induction,during pneumoperitoneum and after extubationTimepoint: During surgery Baseline ,At the end of loading dose 1 minute after endotracheal intubation,Before pneumoperitoneum and 1 minute, 5 minutes ,10 minutes ,15 minutes ,30 minutes ,45 minutes ,60 minutes ,75 minutes after pneumoperitoneum and 5 minutes after release of pneumoperitoneum and After extubation 5 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| bradycardia, tachycardia (HR more than 20% of pre-operative level respectively on two consecutive readings or 100/ min.), clinically significant hypotension and hypertension (MAP less than or more than 20% of pre-operative level respectively on two consecutive readings and sedation score more than Ramsay Sedation Score 4, respiratory depression (SpO2 less than 90%) etc. as adverse effects. Sedation level was measured at 5 minutes after extubationTimepoint: During surgery Baseline ,At the end of loading dose 1 minute after endotracheal intubation,Before pneumoperitoneum and 1 minute, 5 minutes ,10 minutes ,15 minutes ,30 minutes ,45 minutes ,60 minutes ,75 minutes after pneumoperitoneum and 5 minutes after release of pneumoperitoneum and After extubation 5 minutes. | — |
Countries
India
Contacts
Public ContactDebayan Bhattacharya
Department of Anesthesiology Burdwan Medical College & Hospital
Outcome results
None listed