Health Condition 1: null- Patients with symptomatic gallbladder disease who were candidates for elective laparoscopic cholecystectomy.
Conditions
Interventions
Intervention1: Pentoxifylline: A single 400mg tablet once orally 4 hours before surgery.
Control Intervention1: Dexamethasone: A single injection 2ml (8mg) intravenously before induction of anaesthesi
Sponsors
Jawaharlal Nehru Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Patients with symptomatic gallbladder disease who were candidates for elective laparoscopic cholecystectomy.
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative deranged cell counts or cytokine profile. 2. Receipients of corticosteroids or Pentoxifylline or immunoglobulins or immunosuppressive agents within past 4 weeks 3. Hyper sensitivity to pentoxifylline or other xanthines such as caffeine theophylline and theobromine.           4. Patients taking pentoxifylline /corticosteroids for some disease.   5. Severe hepatic impairment 6. Renal impairment        7. Labile blood pressure  8. Existing gastrointestinal ulceration 9. Uncontrolled diabetes mellitus 10. Systemic tuberculosis 11. Severe systemic bacterial, and fungal infections 12 Glaucoma 13. Osteoporosis 14. Immunocompromised state 15. Coagulation disorders 16. Pregnancy Â
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative changes in serum levels of: 1. TNF-α) 2. IL-1β 3. IL-6 4. IL-10 Timepoint: At 6 and 24 hours post surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: Not applicable | — |
Countries
India
Contacts
Public ContactDr Atia Zaka ur Rab
Jawaharlal Nehru Medical College, Aligarh Muslim University
Outcome results
None listed