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Comparison of two different doses of a drug for better comfort of patient during procedure to insert a tube inside their air passage

Comparison of two different doses of dexmedetomidine on patient comfort and hemodynamic parameters during retrograde intubation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013244
Enrollment
60
Registered
2018-04-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with oral cavity cancer

Interventions

Intervention1: Dexmedetomidine 1.5mcg/kg: Dexmedetomidine in a dose of 1.5mcg/kg was given as intravenous infusion for 10min and then retrograde intubation was performed Control Intervention1: Dexmed

Sponsors

Ashish Walian
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1- ASA class 1 and 2 patients 2- Mouth opening less then 2cm due to any pathology 3- MPG grade 3 and 4 4- Thyromental distance less then 4cm 5- Restricted cervical mobility due to bone and joint disorder

Exclusion criteria

Exclusion criteria: 1- Patient not giving consent to participate in the study 2- Patient with nasal mass 3- Patient with hypersensitivity to drug under study 4- Patients with history of ischemic heart disease 5- Patients with baseline heart rate less then 50bpm 6- morbidly obese patients

Design outcomes

Primary

MeasureTime frame
1 Heart rate 2 Systolic blood pressure 3 Diastolic blood pressure 4 Oxygen saturation 5 Observer assessment of sedation scoreTimepoint: Vitals were recorded every minute for 10min during dexmedetomidine infusion and at 0min 1min 5min 10min 15min during the intubation

Secondary

MeasureTime frame
1 Ease of intubation 2 Patient reaction to placement of guidewire and tracheal tube 3 Cough severity 4 patient tolerance to endotracheal tube 5 Intubation time 6 Recall of the procedure 7 Discomfort during the procedureTimepoint: At 1min, 5min, 10min, 15min of intubation and 24hours after surgery

Countries

India

Contacts

Public ContactDr Tanmay Tiwari

King George Medical University

tanmayanesthesia@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026