Health Condition 1: J960- Acute respiratory failure Health Condition 2: null- HYPOXEMIA
Conditions
Interventions
Intervention1: Heated humidified high flow nasal cannula(HHFNC): HFNC is used to provide oxygen in children with respiratory distress.
Control Intervention1: continuous positive airway pressure(CPAP):
Sponsors
Rainbow Childrens Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1 All children in the age group of 1 month to 18 yrs having P/F ratio less than 300 or S/F ratio less than 260.
Exclusion criteria
Exclusion criteria: 1 Children with Severe encephalopathy with Glasgow Coma Scale of below 9 2 Children with poor airway reflexes/ Inadequate spontaneous efforts/inability to clear secretions for example central neurogenic disorder with inability to maintain airway or neuromuscular/musculoskeletal disorders 3 Children with severe shock with multiorgan dysfunction. 4 Children with facial trauma and burns 5 Children with nasal septal defect
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the oxygenation status in both groups. Timepoint: At 1 hrs,6 hrs,24 hrs and 48 hrs. After the calculated sample size of 264 patients with around 132 patients in each arms is reached. This may take December 2018 | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the need for adjunctive respiratory support in the form of need to shift over to CPAP/NIV/INTUBATION for children on HHFNC or NIV/INTUBATION for children on CPAP To assess patient comfort ,mortality ,morbidity , length of stay , PICU stay, atelectasis scoreTimepoint: Time point will depend on the response of the patient. After reaching the calculated sample size of 264 patients which will be roughly 132 patients in each arm by December 2018 | — |
Countries
India
Contacts
Public ContactDr Shashwat Mohanty
Department of Pediatric Intensive Care
Outcome results
None listed