Comparison of dexmedetomidine and dexamethasone as adjuvants to levobupivacaine in axillary brachial plexus block

A comparative study of dexmedetomidine and dexamethasone as adjuvants to levobupivacaine in ultrasound guided axillary brachial plexus block.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/04/013158

Enrollment

Registered

2018-04-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Scheduled for forearm or hand surgery

Interventions

Intervention1: Dexmedetomidine: as adjuvant to levobupivacaine in ultrasound guided axillary brachial plexus block Control Intervention1: Dexamethasone: as adjuvant to levobupivacaine in ultrasound gu

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists (ASA) physical status I and II Scheduled for surgery on forearm or hand

Exclusion criteria

Exclusion criteria: Uncooperative patients, psychiatric problems, inability to understand the information provided or inability to give the consent. Any neurological deficit, peripheral neuropathies, myopathies or chronic pain in the operative limb. History of anaphylaxis to local anaesthetics or known allergy to any of the study drugs to be used. Any history of bleeding diathesis or coagulation abnormalities. Any skin infection or local disease at the needle insertion site.

Design outcomes

Primary

Measure	Time frame
Time to onset of sensory and motor block. Duration of sensory and motor block. Duration of analgesia and total analgesic consumption in 24 hours.Timepoint: Onset of sensory and motor block as the time from end of local anesthetic administration to achievement of complete sensory and motor block respectively. Duration of sensory block as time from onset of sensory block to return of cold sensation. Duration of motor block as time from onset of motor block to return of motor power. Duration of analgesia as time from onset of complete sensory block to first intake of rescue analgesia.	—

Measure

Time frame

Time to onset of sensory and motor block. Duration of sensory and motor block. Duration of analgesia and total analgesic consumption in 24 hours.Timepoint: Onset of sensory and motor block as the time from end of local anesthetic administration to achievement of complete sensory and motor block respectively. Duration of sensory block as time from onset of sensory block to return of cold sensation. Duration of motor block as time from onset of motor block to return of motor power. Duration of analgesia as time from onset of complete sensory block to first intake of rescue analgesia.

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Secondary

Measure	Time frame
Pain scores Adverse effects- Hypotension, Bradycardia, Tachycardia, Hypoxemia, Sedation, Nausea, Vomiting, Pruritis, Skin Rash, Dry mouth, DyspneaTimepoint: Pain assessed by Visual Analogue scale Hypotension(noninvasive blood pressure less than 20% of baseline) Bradycardia(heart rate less than 60beats/minute) Tachycardia(heart rate more than 100beats/minute) Hypoxemia(oxygen saturation less than 90%) Sedation assessed by Modified Ramsay sedation scale Nausea and vomiting assessed by Nausea and vomiting scale.	—

Measure

Time frame

Pain scores Adverse effects- Hypotension, Bradycardia, Tachycardia, Hypoxemia, Sedation, Nausea, Vomiting, Pruritis, Skin Rash, Dry mouth, DyspneaTimepoint: Pain assessed by Visual Analogue scale Hypotension(noninvasive blood pressure less than 20% of baseline) Bradycardia(heart rate less than 60beats/minute) Tachycardia(heart rate more than 100beats/minute) Hypoxemia(oxygen saturation less than 90%) Sedation assessed by Modified Ramsay sedation scale Nausea and vomiting assessed by Nausea and vomiting scale.

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Countries

India

Contacts

Public ContactTania Singh

Dayanand Medical College and Hospital, Ludhiana

drdineshsood@gmail.com9814020817

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026