Role of intraocular injection of antibiotic "Moxifloxacin" during cataract surgery for prevention of post-cataract surgery infection

Efficacy of Prophylactic Use of Intracameral Moxifloxacin 0.5% in Prevention of Post-Cataract Surgery Endophthalmitis: A Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/04/013149

Enrollment

15000

Registered

2018-04-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Cataract Health Condition 2: H259- Unspecified age-related cataract

Interventions

Intervention1: Moxifloxacin 0.5%: intracameral moxifloxacin hydrochloride o.5% will be administered immediately after the surgery. only one dose will be administered. Control Intervention1: none: none

Eligibility

Inclusion criteria

Inclusion criteria: a. Patients with senile cataract undergoing phacoemulsification b. Age > 40 years c. Patient willing for follow up

Exclusion criteria

Exclusion criteria: a. Complicated cataract b. Previous intraocular surgery c. Age d. Adnexal infections/ Active blepharitis/ Atopic keratoconjunctivitis f. Patients not willing for follow-up

Design outcomes

Primary

Measure	Time frame
Rate of endophthalmitisTimepoint: preoperative post operative 1 day, 1 week, 3 weeks and 6 weeks	—

Secondary

Measure	Time frame
1.UDVA 2.BCVA 3.Intraocular Pressure 4.central corneal thickness 5.Endothelial cell density 6.Central macular thickness (OCT) 7.Vitreous haze Timepoint: preoperative post operative 1 day, 1 week, 3 weeks and 6 weeks	—

Countries

India

Contacts

Public ContactNamrata Sharma

Dr R P Centre for Ophthalmic Sciences

namrata.sharma@gmail.com9810856988

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026