Health Condition 1: null- Acanthameba keratitis
Conditions
Interventions
Intervention1: voriconazole: Ophthalmic Eye drops
Control Intervention1: Polyhexamethylene biguanide and Chlorhexidine: Ophthalmic Eye drops
Sponsors
L V Prasad Eye Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age equal to or more than 18 years. 2) Male or female 3) Stromal infiltrate size between 2-6 mm. 4) Corneal scraping positive for Acanthamoeba cysts in direct smear examination by any one or more of the methods used.
Exclusion criteria
Exclusion criteria: 1) The corneal scrapings are negative for Acanthamoeba. 2) The patient has a history of allergy to voriconazole or chlorhexidine 3) The cornea or sclera has been perforated or perforation is impending. 4) The unaffected eye is legally blind. . 5) The patient is known to be HIV positive or diabetic. 6) The initial culture shows significant growth of bacteria ( >10 colonies) or fungus. 7) Both eyes are infected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment failure â?? failure to induce a favorable clinical response within two weeks of initiating therapy with either voriconazole or combined therapy.Timepoint: 2 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to healing, visual acuity change, scarTimepoint: 2 weeks | — |
Countries
India
Contacts
Public ContactDr Bhupesh Bagga
LV Prasad Eye Institute
Outcome results
None listed