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A clinical trial to study the incidence and intensity of injection pain of two different formulations of drug propofol in patients requirin general anaesthesia

â??Propofol injection pain: a prospective double-blind trial of a Medium Chain Triglyceride/Long Chain Triglyceride (MCT/LCT) propofol formulation versus Long Chain Triglyceride (LCT)propofol formulation â??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013125
Enrollment
200
Registered
2018-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1 and ASA 2

Interventions

Intervention1: Propofol MCT/LCT (medium chain triglyceride/long chain triglyceride): 30 mg (3 cc) of propofol MCT/LCT injected intravenously over 20 sec Control Intervention1: Propofol LCT: 3o mg (3 c

Sponsors

SDM College of Medical Sciences and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.The subjects who are aged between 18 to 60 years belonging to ASA Physical status 1 and 2. 2. Those willing to participate.

Exclusion criteria

Exclusion criteria: 1.Patients with ischaemic heart diseases, neurological or psychiatric problems, renal or hepatic insufficiency, suspected or known airway difficulty. 2. Pregnant or lactating women. 3. Those who were taking any analgesics before surgery. 4. Those with known hypersensitivity to propofol or to any of the constituents of emulsion. 5. Those who refuse to give consent.

Design outcomes

Primary

MeasureTime frame
pain on propofol induction and pain recall postoperatively. Verbal rating scale for injection pain and recall pain used.Timepoint: Following 3cc of propofol induction pain will be assessed after 30 secs. Full dose of propofol will be given after assessing pain. Pain recall postoperatively 30 mins after the patient is shifted to post operative ward

Secondary

MeasureTime frame
changes in Pulse rate, Non invasive Blood pressure and SaturationTimepoint: pre induction, induction, postoperatively

Countries

India

Contacts

Public ContactSupreeth R Shetty

Mandya institute of medical sciences

mcbsanthu@gmail.com9886811263

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026