FindTrial
Sign In

Effect of changing electrical parameters of electroconvulsive therapy (ECT) on outcome and its side effects in people with schizophrenia

Comparison of cognitive adverse effects, seizure threshold and efficacy of 2 pulse frequencies (50pps and 125pps) during brief pulse ECT in schizophrenia patients- A double blind randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013121
Enrollment
100
Registered
2018-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F20- Schizophrenia

Interventions

Intervention1: Pulse frequency of 125 pulses per second in ECT: Bifrontal ECT with electric current of Pulse frequency of 125 pulses per second Pulse width 1.5 second, Amplitude of 800 mAmpere Interv

Sponsors

Dr Preeti Sinha
Lead Sponsor
Jagadisha Thirthalli
Collaborator
Naveen Kumar C
Collaborator
Shyam Sundar A
Collaborator
Sudhir V
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosed with Schizophrenia according to DSM-5 2. Referred to receive Bifrontal ECT 3. Able to read and write in Kannada or English or Hindi. 4. Provides consent for study

Exclusion criteria

Exclusion criteria: 1. ECT within last 3months 2. Mental retardation 3. Comorbid seizure disorders and organic brain disorders 4. Patients with neurological illness which would effect the cognitive functions and psychopathology will be excluded from the study. 5. Patients with a diagnosis of substance use disorder (except nicotine use disorder)

Design outcomes

Primary

MeasureTime frame
Verbal Memory (delayed Recall) Autobiographical MemoryTimepoint: 1 or 2 days before 1st ECT Within 2 days after 6th or last ECT, whichever is earlier—

Secondary

MeasureTime frame
Duration of pupillary non-response during ECT induced seizureTimepoint: During 2nd ECT During 6th ECT;Iictal and post ictal fractal dimension of EEG recordingsTimepoint: During 2nd ECT During 6th ECT;Other cognitive outcomes- Verbal Fluency, Verbal memory (Immediate Recall), Visual memory, Working memoryTimepoint: Before 1st ECT After 6th or Last ECT, whichever is earlier;Over all clinical status through standardised scales- Nurses Observation Scale for Inpatient Evaluation (NOSIE) Brief Psychiatric Rating Scale (BPRS) Clinical Global impression-Severity (CGI-S)Timepoint: Before 1st ECT After 6th or Last ECT, whichever is earlier;Percentage increase in (RPP) Heart Rate Systolic Blood Pressure Product during ECT induced seizureTimepoint: During 2nd ECT During 6th ECT;Seizure thresholdTimepoint: During 1st ECT;Specific clinical outcomes- Bush Francis Catatonia Rating Scale Calgary Depression Scale for SchizophreniaTimepoint: Before 1st ECT After 6th or Last ECT, whichever is earlier—

Countries

India

Contacts

Public ContactPreeti Sinha

National Institute of Mental Health and Neurosciences, (NIMHANS)

drpreetisinha@gmail.com9243328988

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026