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Comparision of two different drugs (Dexmedetomidine and Midazolam) as an adjuvant to local anaesthetic drug in spinal anaesthesia for lower limb surgeries.

Dexmedetomidine versus Midazolam as adjuvant to hyperbaric Bupivacaine in spinal anaesthesia in lower limb orthopaedic surgeries:A double blind randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013098
Enrollment
80
Registered
2018-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- 18-60 yrs age of either of sex posted for lower limb orthopedic surgery

Interventions

Intervention1: Dexmeditomide: Alpha 2 agonist agent with anxiolytic,anaesthetic,hypnotic and analgesic properties. Control Intervention1: Midazolam: It is water soluble imidazole-benzodiazepine. It ha

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA Physical status I and II 2.Posted for elective lower limb orthopedic surgeries

Exclusion criteria

Exclusion criteria: 1.Patient refusing to participate in the study 2.Allergy to amide local anaesthetic 3.Patient with ischemic heart block and Dysarhythmias 4.Patient taking alpha 2 antagonist,ACE inhibitors,Calcium Channel blokers and Beta Blokers

Design outcomes

Primary

MeasureTime frame
Duration of sensory blockTimepoint: 1)Onset of sensory blockade at L1 2)Highest sensory level achieved 3)Time to achieve highest sensory level 4)Two segment regression time from highest sensory level. 5)Time for regression upto level L1 from highest sensory level.—

Secondary

MeasureTime frame
Onset and highest level of sensory and motor blockTimepoint: Time of drug injection to achievement of highest level of sensory and motor block—

Countries

India

Contacts

Public ContactLigiya George T

Medical College Baroda

mgpatel111@yahoo.com9825453024

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026