Comparison of three liquid media instilled in endotracheal tube cuff on haemodynamic changes and postoperative cough,sore throat in neurosurgical patients.

Comparison of the efficacy of intracuff saline, 1% alkalinized lignocaine and 2% alkalinized lignocaine on endotracheal tube induced haemodynamic changes and emergence phenomena in neurosurgical patients.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/04/013067

Enrollment

Registered

2018-04-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Neurosurgical cases of age 18-65 years ASA Grade I and II

Interventions

Intervention1: 2% alkalinized lignocaine group: Patients in this group will be given general anaesthesia(preoxygenation with 100% oxygen for 3 min, patients will be induced with Inj Fentanyl 1.5 Î¼g/

Eligibility

Inclusion criteria

Inclusion criteria: 1.Neurosurgical cases of age 18-65 years, either gender with American Society of Anaesthesiologistâ??s Grade I and Grade II and Glasgow coma scale (GCS)-15/15. 2.Duration of surgery >1 hr.

Exclusion criteria

Exclusion criteria: 1.Patients with history of sorethroat/URTI/ laryngeal or tracheal pathology; asthma /COPD; Stridor / Dysphonia; Oropharyngeal and or neck malformations. 2.Patients with predicted difficult intubation / >2 attempts of intubation. 3.Patients receiving intravenous lignocaine / allergic to Local Anaesthetics. 4.Patients who are not immediately extubated after surgery. 5.Usage of nasogastric / orogastric tube inrtaoperatively

Design outcomes

Primary

Measure	Time frame
To compare the incidence of post extubation cough (PEC) and postoperative sore throat (POST)Timepoint: 1 hour, 8 hours and 24 hours postoperative period	—

Secondary

Measure	Time frame
1)Haemodynamic changes 2)Postoperative dysphonia,dysphagia 3)Postoperative pain,nausea and vomiting 4)Smooth extubationTimepoint: At the time of intubation, during the surgery, at the time of extubation and postoperative period	—

Countries

India

Contacts

Public ContactDr Mounisha E

Vardhman Mahavir Medical College and Safdarjung Hospital

drvandanatalwar@gmail.com9811352251

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026