to compare dexmedetomidine versus nitroglycerine as a hypotensive agent causing less blood loss in posterior fixation surgery of spine.

COMPARISON OF EFFICACY OF DEXMEDETOMIDINE VERSUS NITROGLYCERINE AS A HYPOTENSIVE AGENT IN PATIENTS UNDERGOING POSTERIOR FIXATION SURGERY OF SPINE

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2018/04/013065

Enrollment

Registered

2018-04-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- age 18-65yrs ,ASA I and II

Interventions

Control Intervention1: dexmedetomidine: After induction of general anaesthesia,Patients in the group A will be infused intravenously with a loading dose of dexmedetomidine 1mcg/kg diluted in 10ml of 0

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of age 18-65yrs undergoing posterior fixation of spine surgery under general anaesthesia 2. ASA I and II

Exclusion criteria

Exclusion criteria: 1. Patients with hypertension 2. Patients with history of significant systemic disorders ( like cardiovascular, respiratory , central nervous system, hepatic and renal ) 3. Patients with bleeding disorders.

Design outcomes

Primary

Measure	Time frame
To compare intra-operative haemodynamic changes and blood loss with infusion of dexmedetomidine and nitroglycerine in patients undergoing posterior fixation surgery of spine.Timepoint: intra-operative	—

Secondary

Measure	Time frame
To compare the recovery characteristics and side effects of both these drugs in patients undergoing posterior fixation surgery of spine.Timepoint: intra-operative	—

Countries

India

Contacts

Public Contactchandrika priyadarshini

VMMC AND SAFDARJUNG HOSPITAL,NEW DELHI

Jeetendrabajaj@gmail.com9810465070

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026