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To study the effect of dexmedetomidine on brain electrical activity during surgery for epilepsy

Effect of dexmedetomidine on electrocorticography in patients undergoing epilepsy surgery under desflurane anaesthesia â?? a randomised controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/013017
Enrollment
30
Registered
2018-04-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- medically intractable epilepsy scheduled to undergo epilepsy surgery under desflurane general anesthesia

Interventions

Intervention1: Inj. Dexmedetomidine: 0.5µg/kg diluted to 10mL, administered intravenously over duration of 10 minutes. Control Intervention1: Normal Saline - Control: Normal saline, 10mL volume, admi

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 17 and 60, with medically intractable epilepsy and a well-defined lesion on MRI, scheduled to undergo surgical resection of the epileptogenic focus with the use of ECoG guidance under general anaesthesia will be enrolled.

Exclusion criteria

Exclusion criteria: We will exclude patients with a history of hypertension, arrhythmias, ischemic heart disease, morbid obesity, pregnancy or known allergy to the drugs used.

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of dexmedetomidine on the quality of ECoG recordings in patients undergoing epilepsy surgery under desflurane anaesthesiaTimepoint: Intraoperatively—

Secondary

MeasureTime frame
To evaluate the effect of dexmedetomidine on hemodynamic parameters in patients undergoing epilepsy surgery To determine the effect of dexmedetomidine on the emergence time and extubation time in epilepsy surgery To determine the effect of dexmedetomidine on the neurological outcome at discharge in these patients Timepoint: intraoperatively, at discharge—

Countries

India

Contacts

Public ContactSiddharth Chavali

All India Institute of Medical Sciences

prabhakaraiims@yahoo.co.in9868398205

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026